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KMID : 1161420150180040409
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Journal of Medicinal Food
2015 Volume.18 No. 4 p.409 ~ p.414
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Nobiletin Protects Dopaminergic Neurons in the 1-Methyl-4-Phenylpyridinium-Treated Rat Model of Parkinson's Disease
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Jeong Kyoung-Hoon
Jeon Min-Tae
Kim Heung-Deok
Jung Un-Ju
Jang Min-Cheol
Chu Jin-Woo
Yang Seung-Jun
Choi Il-Yoon
Choi Myung-Sook
Kim Sang-Ryong
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Abstract
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This study investigated the effect of nobiletin, a flavonoid found in citrus fruits, on the degeneration of dopaminergic (DA) neurons in a neurotoxin model of Parkinson's disease (PD). 1-Methyl-4-phenylpyridinium (MPP+) was unilaterally injected into the median forebrain bundle of rat brains (to generate a neurotoxin model of PD) with or without daily intraperitoneal injection of nobiletin. Our results showed that nobiletin treatment at 10?mg/kg bw, but not at 1 or 20?mg/kg bw, significantly protected DA neurons in the substantia nigra (SN) of MPP+-treated rats. In parallel to the neuroprotection, nobiletin treatment at 10?mg/kg inhibited microglial activation and preserved the expression of the glial cell line-derived neurotrophic factor, which is a therapeutic agent against PD, in the SN. These results suggest that the proper supplementation with nobiletin may protect against the neurodegeneration involved in PD.
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KEYWORD
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dopaminergic neuron, GDNF, microglia, MPP+, neuroprotection, nobiletin
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